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To investigate whether intrapartum administration of dexamethasone would reduce the risk of institutionalization of women at delivery, and to examine whether the outcome would be influenced by infant gender and birth weight. The secondary analysis is a substudy of randomized trial of 841 low-risk pregnant women who were assigned to either intrapartum glucocorticoid or placebo. We grouped them into those receiving a single dose of dexamethasone or a placebo. The primary outcome was the occurrence of institutionalization within 2 years of delivery. Institutionalization was defined as placement in a nursing facility for at least 30 days, or death while in the institution. Relative risks (RRs) and 95% confidence intervals (CIs) of institutionalization and an increased RR after adjusting for confounding variables such as birth weight and infant gender, were calculated. The RRs were 0.61 (95% CI, 0.46 to 0.81) in the whole sample, 0.41 (95% CI, 0.18 to 0.92) in the dexamethasone group, and 0.66 (95% CI, 0.43 to 1.04) in the placebo group. In conclusion, administration of intrapartum glucocorticoids was associated with a decreased risk of institutionalization at 2 years after delivery.Britain’s Prime Minister Theresa May speaks during a joint news conference with European Commission